Cerebral Cortex, Vol. 12, No. 5, 453-465,
May 2002
© 2002 Oxford University Press
Early Specification of the Hierarchical Organization of Visual Cortical Areas in the Macaque Monkey
Cerveau et Vision INSERM 371, 18 Avenue du Doyen Lépine, 69675 Bron Cedex and , 1 Faculté de Médecine Lyon Sud, Service de Gynécologie Obstétrique, Centre Hospitalier Lyon Sud, 165 Chemin du Grand Revoyet, 69495 Pierre Bénite Cedex, France
Henry Kennedy, Cerveau et Vision INSERM 371, 18 Avenue du Doyen Lépine, 69675 Bron Cedex, France. Email: kennedy{at}lyon151.inserm.fr.
The laminar organization of cortico-cortical projection neurons (expressed by the percentage of supragranular projecting neurons – SLN%) characterizes cortical pathways as feedforward (FF) or feedback (FB) and determines the hierarchical ranking of cortical areas. There is evidence of a developmental reduction in SLN% of pathways to area V1. Here, by analyzing pre- and postnatal projections to area V4, we have been able to address whether developmental reductions of SLN% impact on information processing in the immature cortex. FB pathways to area V4 exhibit 28–84% reduction of SLN%. This contrasts with the FF projections, which show little or no SLN% reduction. However, SLN% values in the immature cortex allocated cortical areas to the same hierarchical levels as in the adult. The developmental reduction of SLN% is a widespread phenomenon in the neocortex and is a distinctive feature of FB pathways. Two mechanisms contribute to developmental changes in SLN%: (i) delayed ingrowth of axons into the cortical target from infragranular layer neurons and (ii) prolonged developmental reduction of the divergence of projections from supragranular layer neurons. The present results show that FF and FB projections exhibit different developmental processes and patterns of connections linking cortical areas and their hierarchical relations are established prenatally, independently of regressive phenomena.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Zheng, B. Zhang, H. Bi, I. Maruko, I. Watanabe, C. Nakatsuka, E. L. Smith 3rd, and Y. M. Chino Development of Temporal Response Properties and Contrast Sensitivity of V1 and V2 Neurons in Macaque Monkeys J Neurophysiol, June 1, 2007; 97(6): 3905 - 3916. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zhang, H. Bi, E. Sakai, I. Maruko, J. Zheng, E. L. Smith III, and Y. M. Chino Rapid plasticity of binocular connections in developing monkey visual cortex (V1) PNAS, June 21, 2005; 102(25): 9026 - 9031. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kral, J. Tillein, S. Heid, R. Hartmann, and R. Klinke Postnatal Cortical Development in Congenital Auditory Deprivation Cereb Cortex, May 1, 2005; 15(5): 552 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhang, J. Zheng, I. Watanabe, I. Maruko, H. Bi, E. L. Smith III, and Y. Chino Delayed maturation of receptive field center/surround mechanisms in V2 PNAS, April 19, 2005; 102(16): 5862 - 5867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Komatsu, A. Watakabe, T. Hashikawa, S. Tochitani, and T. Yamamori Retinol-binding Protein Gene is Highly Expressed in Higher-order Association Areas of the Primate Neocortex Cereb Cortex, January 1, 2005; 15(1): 96 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rodriguez, J. Whitson, and R. Granger Derivation and Analysis of Basic Computational Operations of Thalamocortical Circuits J. Cogn. Neurosci., June 1, 2004; 16(5): 856 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Noppeney, K. J. Friston, and C. J. Price Effects of visual deprivation on the organization of the semantic system Brain, July 1, 2003; 126(7): 1620 - 1627. [Abstract] [Full Text] [PDF]
|
|