Cerebral Cortex, Vol. 12, No. 2, 187-198,
February 2002
© 2002 Oxford University Press
Relationships of Local Inhibitory and Excitatory Circuits to Orientation Preference Maps in Ferret Visual Cortex
Department of Anatomy and Neurobiology, School of Medicine, University of Maryland at Baltimore, 685 West Baltimore Street, Baltimore, MD 21201-1509, USA
Birgit Roerig, Department of Anatomy and Neurobiology, School of Medicine, University of Maryland at Baltimore, 685 West Baltimore Street, Baltimore, MD 21201-1509, USA. Email: broer001{at}umaryland.edu.
The contribution and precise role of intracortical circuits in generating orientation tuned responses in visual cortical neurons is still controversial. To address this question, the relationship between excitatory and inhibitory synaptic connections and orientation maps in ferret striate cortex was investigated by combining in vivo optical imaging and in vitro scanning laser photostimulation. Excitatory and inhibitory inputs to pyramidal cells originated preferentially from regions with similar orientation preference. Prominent cross-orientation inhibition was not observed, arguing against cross-orientation models of orientation selectivity. The tuning of inhibitory inputs was significantly broader in both layer 2/3 and layer 5/6 pyramidal neurons compared to the tuning of excitatory inputs. Local excitatory inputs were more prominent in the 0–20° tuning difference range between pre- and postsynaptic cells than inhibitory inputs, whereas inhibition dominated in the 20–40° tuning difference range. These differences in tuning of excitatory and inhibitory inputs onto individual cells are consistent with the predictions of recurrent models of orientation selectivity.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Borgers, S. Epstein, and N. J. Kopell Gamma oscillations mediate stimulus competition and attentional selection in a cortical network model PNAS, November 18, 2008; 105(46): 18023 - 18028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Chelaru and V. Dragoi Asymmetric Synaptic Depression in Cortical Networks Cereb Cortex, April 1, 2008; 18(4): 771 - 788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Sengpiel, K.-U. Jirmann, V. Vorobyov, and U. T. Eysel Strabismic Suppression Is Mediated by Inhibitory Interactions in the Primary Visual Cortex Cereb Cortex, December 1, 2006; 16(12): 1750 - 1758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-W. Lam and S. M. Sherman Mapping by Laser Photostimulation of Connections Between the Thalamic Reticular and Ventral Posterior Lateral Nuclei in the Rat J Neurophysiol, October 1, 2005; 94(4): 2472 - 2483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Sengpiel and V. Vorobyov Intracortical Origins of Interocular Suppression in the Visual Cortex J. Neurosci., July 6, 2005; 25(27): 6394 - 6400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Carreira-Perpinan and G. J. Goodhill Influence of Lateral Connections on the Structure of Cortical Maps J Neurophysiol, November 1, 2004; 92(5): 2947 - 2959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Martinez and J.-M. Alonso Complex Receptive Fields in Primary Visual Cortex Neuroscientist, October 1, 2003; 9(5): 317 - 331. [Abstract] [PDF]
|
|
|
|
|
|
K. A. Razak, L. Huang, and S. L. Pallas NMDA Receptor Blockade in the Superior Colliculus Increases Receptive Field Size Without Altering Velocity and Size Tuning J Neurophysiol, July 1, 2003; 90(1): 110 - 119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Roerig, B. Chen, and J. P.-Y. Kao Different Inhibitory Synaptic Input Patterns in Excitatory and Inhibitory Layer 4 Neurons of Ferret Visual Cortex Cereb Cortex, April 1, 2003; 13(4): 350 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Lund, A. Angelucci, and P. C. Bressloff Anatomical Substrates for Functional Columns in Macaque Monkey Primary Visual Cortex Cereb Cortex, January 1, 2003; 13(1): 15 - 24. [Abstract] [Full Text] [PDF]
|
|