Cerebral Cortex, Vol. 12, No. 12, 1331-1341,
December 2002
© 2002 Oxford University Press
A Computational Morphometric MRI Study of Schizophrenia: Effects of Hallucinations
Departments of Psychological Medicine and Neuroimaging, Institute of Psychiatry, London SE5 8AF, , 1 Department of Psychiatry, University of Cambridge, Addenbrooke’s Hospital, Cambridge, CBT 2QQ and , 2 Academic Department of Psychiatry, University of Sheffield, The Longley Centre (Northern General Hospital), Norwood Grange Road, Sheffield S5 7JT, UK
Address correspondence to Anthony S. David, Section of Cognitive Neuropsychiatry (Box 68), Institute of Psychiatry, London SE5 8AF, UK. Email: a.david{at}iop.kcl.ac.uk.
Quantitative magnetic resonance imaging (MRI) studies in patients with schizophrenia have shown reliable deficits in global tissue volume as well as some regionally specific changes, particularly in the temporal and frontal lobes. Recent technical advances have enabled automated voxel-wise analyses, which have the advantage of facilitating whole brain coverage without the restrictions of anatomically defined regions of interest and imperfect rater reliability. We used such a method to estimate voxel composition from segmentation of bivariate, dual-echo spin-echo data in 72 men with schizophrenia. Of these, 41 had a prominent history of auditory– verbal hallucinations and 31 had no such history. The patients were compared with 32 age, gender, handedness and IQ matched healthy controls. The study revealed localized areas of reduced grey-matter tissue proportion aggregating around the medial temporal lobes, the insulae, orbito-frontal cortex including anterior cingulate, and the precuneus (and lingual) gyri, in the schizophrenia patients as a whole. There were also reductions in white-matter tissue proportion extending along much of the large anterior–posterior frontal tracts in the right hemisphere. Small regions of increased grey matter were also noted in the right inferior parietal lobe. A contrast between the hallucinator and non-hallucinator patient groups showed a single region of reduced grey-matter tissue proportion affecting the left insula and adjacent temporal lobe. These data confirm the utility of voxel-based morphometric methods in schizophrenia research and point towards disruption to a ‘paralimbic’ neural network, as underlying schizophrenic psychopathology in general, with abnormalities of the left insula specifically related to hallucinations.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Fornito, M. Yucel, B. Dean, S. J. Wood, and C. Pantelis Anatomical Abnormalities of the Anterior Cingulate Cortex in Schizophrenia: Bridging the Gap Between Neuroimaging and Neuropathology Schizophr Bull, September 1, 2009; 35(5): 973 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. K. Chan, X. Di, G. M. McAlonan, and Q.-y. Gong Brain Anatomical Abnormalities in High-Risk Individuals, First-Episode, and Chronic Schizophrenia: An Activation Likelihood Estimation Meta-analysis of Illness Progression Schizophr Bull, July 24, 2009; (2009) sbp073v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Segall, J. A. Turner, T. G.M. van Erp, T. White, H. J. Bockholt, R. L. Gollub, B. C. Ho, V. Magnotta, R. E. Jung, R. W. McCarley, et al. Voxel-based Morphometric Multisite Collaborative Study on Schizophrenia Schizophr Bull, January 1, 2009; 35(1): 82 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Ellison-Wright, D. C. Glahn, A. R. Laird, S. M. Thelen, and E. Bullmore The Anatomy of First-Episode and Chronic Schizophrenia: An Anatomical Likelihood Estimation Meta-Analysis Am J Psychiatry, August 1, 2008; 165(8): 1015 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Hoffman, M. Hampson, K. Wu, A. W. Anderson, J. C. Gore, R. J. Buchanan, R. T. Constable, K. A. Hawkins, N. Sahay, and J. H. Krystal Probing the Pathophysiology of Auditory/Verbal Hallucinations by Combining Functional Magnetic Resonance Imaging and Transcranial Magnetic Stimulation Cereb Cortex, November 1, 2007; 17(11): 2733 - 2743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Coltheart, R. Langdon, and R. McKay Schizophrenia and Monothematic Delusions Schizophr Bull, May 1, 2007; 33(3): 642 - 647. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Dean, P. Fearon, K. Morgan, G. Hutchinson, K. Orr, X. Chitnis, J. Suckling, R. Mallet, J. Leff, P. B. Jones, et al. Grey matter correlates of minor physical anomalies in the AeSOP first-episode psychosis study The British Journal of Psychiatry, September 1, 2006; 189(3): 221 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Dazzan, K. D. Morgan, X. Chitnis, J. Suckling, C. Morgan, P. Fearon, P. K. McGuire, P. B. Jones, J. Leff, and R. M. Murray The Structural Brain Correlates of Neurological Soft Signs in Healthy Individuals Cereb Cortex, August 1, 2006; 16(8): 1225 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Honea, T. J. Crow, D. Passingham, and C. E. Mackay Regional Deficits in Brain Volume in Schizophrenia: A Meta-Analysis of Voxel-Based Morphometry Studies Am J Psychiatry, December 1, 2005; 162(12): 2233 - 2245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Honey, E. Pomarol-Clotet, P. R. Corlett, R. A. E. Honey, P. J. Mckenna, E. T. Bullmore, and P. C. Fletcher Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function Brain, November 1, 2005; 128(11): 2597 - 2611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. C. Mitchell, R. Elliott, M. Barry, A. Cruttenden, and P. W. R. Woodruff Neural response to emotional prosody in schizophrenia and in bipolar affective disorder The British Journal of Psychiatry, March 1, 2004; 184(3): 223 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Dazzan, K. D. Morgan, K. G. Orr, G. Hutchinson, X. Chitnis, J. Suckling, P. Fearon, J. Salvo, P. K. McGuire, R. M. Mallett, et al. The structural brain correlates of neurological soft signs in AeSOP first-episode psychoses study Brain, January 1, 2004; 127(1): 143 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. R. Kuperberg, M. R. Broome, P. K. McGuire, A. S. David, M. Eddy, F. Ozawa, D. Goff, W. C. West, S. C. R. Williams, A. J. W. van der Kouwe, et al. Regionally Localized Thinning of the Cerebral Cortex in Schizophrenia Arch Gen Psychiatry, September 1, 2003; 60(9): 878 - 888. [Abstract] [Full Text] [PDF]
|
|