Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (28)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Highley, J. R.
Right arrow Articles by Harrison, P. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Highley, J. R.
Right arrow Articles by Harrison, P. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol. 12, No. 11, 1218-1224, November 2002
© 2002 Oxford University Press

Asymmetry of the Uncinate Fasciculus: A Post-mortem Study of Normal Subjects and Patients with Schizophrenia

J. Robin Highley1, Mary A. Walker1, Margaret M. Esiri1, Timothy J. Crow1,2 and Paul J. Harrison1,3

1 Schizophrenia Research Group, Department of Clinical Neurology (Neuropathology), Radcliffe Infirmary, , 2 POWIC, University Department of Psychiatry, Warneford Hospital and , 3 Neurosciences Building, University Department of Psychiatry, Warneford Hospital, Oxford, UK

Address correspondence to Professor P.J. Harrison, Neurosciences Building, University Department of Psychiatry, Warneford Hospital, Oxford, OX3 7JX, UK. Email: paul.harrison{at}psych.ox.ac.uk.

The uncinate fasciculus interconnects the anterior temporal and inferior frontal lobes. The temporal lobes show a number of anatomical asymmetries, some of which are altered in schizophrenia. This study was performed to assess the size and symmetry of the uncinate fasciculus in normal subjects and in patients with the disorder. The area, fibre density and total fibre number of left and right uncinate fasciculi were estimated using stereological methods in 21 control subjects and 17 schizophrenics. The uncinate fasciculus was found to be asymmetrical in both sexes, being 27% larger and containing 33% more fibres in the right than the left hemisphere. Of the 25 brains from which both hemispheres were available, the size asymmetry was seen in 20 subjects and the greater number of fibres in 21 subjects. There was no significant effect of schizophrenia upon the uncinate fasiculus, nor interactions of diagnosis with side or sex. We conclude that the uncinate fasciculus is larger in the right hemisphere, perhaps indicating greater right-sided fronto-temporal connectivity. The unchanged size of the fasciculus in schizophrenia contrasts with commissural tracts, which are affected in this brain series in a sex-specific manner.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
G. Gong, Y. He, L. Concha, C. Lebel, D. W. Gross, A. C. Evans, and C. Beaulieu
Mapping Anatomical Connectivity Patterns of Human Cerebral Cortex Using In Vivo Diffusion Tensor Imaging Tractography
Cereb Cortex, June 20, 2008; (2008) bhn102v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
H Duffau, M T. de Schotten, and E Mandonnet
White matter functional connectivity as an additional landmark for dominant temporal lobectomy
J. Neurol. Neurosurg. Psychiatry, May 1, 2008; 79(5): 492 - 495.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
S. Rodrigo, O. Naggara, C. Oppenheim, N. Golestani, C. Poupon, Y. Cointepas, J.F. Mangin, D. Le Bihan, and J.F. Meder
Human Subinsular Asymmetry Studied by Diffusion Tensor Imaging and Fiber Tracking
AJNR Am. J. Neuroradiol., September 1, 2007; 28(8): 1526 - 1531.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
J. D. Schmahmann, D. N. Pandya, R. Wang, G. Dai, H. E. D'Arceuil, A. J. de Crespigny, and V. J. Wedeen
Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography
Brain, March 1, 2007; 130(3): 630 - 653.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
T. Taoka, S. Iwasaki, M. Sakamoto, H. Nakagawa, A. Fukusumi, K. Myochin, S. Hirohashi, T. Hoshida, and K. Kichikawa
Diffusion anisotropy and diffusivity of white matter tracts within the temporal stem in Alzheimer disease: evaluation of the "tract of interest" by diffusion tensor tractography.
AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 1040 - 1045.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
J. R. Highley, M. A. Walker, T. J. Crow, M. M. Esiri, and P. J. Harrison
Low Medial and Lateral Right Pulvinar Volumes in Schizophrenia: A Postmortem Study
Am J Psychiatry, June 1, 2003; 160(6): 1177 - 1179.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
J. BURNS, D. JOB, M. E. BASTIN, H. WHALLEY, T. MACGILLIVRAY, E. C. JOHNSTONE, and S M. LAWRIE
Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study
The British Journal of Psychiatry, May 1, 2003; 182(5): 439 - 443.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.