Cerebral Cortex, Vol. 12, No. 10, 1092-1100,
October 2002
© 2002 Oxford University Press
Homeostatic Control of Slow-wave and Spindle Frequency Activity during Human Sleep: Effect of Differential Sleep Pressure and Brain Topography
Center for Chronobiology, Psychiatric University Clinic, CH-4025 Basel, Switzerland
Address correspondence to Christian Cajochen, Center for Chronobiology, Wilhelm Kleinstrasse 27, CH-4025 Basel, Switzerland. Email: christian.cajochen{at}pukbasel.ch.
The impact of a 40 h sleep deprivation versus a 40 h multiple nap paradigm on topographic and temporal aspects of electroencephalo-graphic (EEG) activity during the subsequent recovery sleep was investigated in 10 young volunteers in a controlled ‘constant posture’ protocol. The accumulation of sleep pressure with extended wakefulness could be significantly attenuated by intermittent naps. The differential sleep pressure conditions induced frequency- and topographic-specific changes in the EEG slow wave range (0.5–5 Hz) and in the low (LSFA, 12.25–13.25 Hz) and high spindle frequency activity range (HSFA, 13.75–16.5 Hz) during non-REM sleep. The observed increase of EEG slow-wave activity (SWA) after high sleep pressure was significantly more pronounced in the fronto-central (Fz, Cz) than in the parieto-occipital (Pz, Oz) derivations. Low sleep pressure after the nap paradigm decreased SWA with an occipital predominance. Spindle frequency activity showed a dissimilar homeostatic regulation: HSFA was significantly decreased after high sleep pressure and increased after low sleep pressure, exclusively in the centro-parietal brain region (Cz, Pz). LSFA was significantly enhanced after both manipulations. The data indicate that EEG activity, in particular frontal SWA and centro-parietal HSFA, are under a clear sleep–wake-dependent homeostatic control and imply a reciprocal relationship in the homeostatic regulation of SWA and HSFA, which however shows different spatio-temporal aspects.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Vollenweider, A. Wirz-Justice, J. Flammer, S. Orgul, and K. Krauchi Chronobiological characterization of women with primary vasospastic syndrome: body heat loss capacity in relation to sleep initiation and phase of entrainment Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R630 - R638. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. V. Retey, M. Adam, E. Honegger, R. Khatami, U. F. O. Luhmann, H. H. Jung, W. Berger, and H.-P. Landolt A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans PNAS, October 25, 2005; 102(43): 15676 - 15681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Merica and R. D Fortune A Unique Pattern of Sleep Structure is Found to be Identical at all Cortical Sites: a Neurobiological Interpretation Cereb Cortex, October 1, 2003; 13(10): 1044 - 1050. [Abstract] [Full Text] [PDF]
|
|