Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (37)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Brooks, J. C.W.
Right arrow Articles by Whitehouse, G. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brooks, J. C.W.
Right arrow Articles by Whitehouse, G. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol. 11, No. 7, 598-605, July 2001
© 2001 Oxford University Press

A Proton Magnetic Resonance Spectroscopy Study of Age-related Changes in Frontal Lobe Metabolite Concentrations

Jonathan C.W. Brooks1, Neil Roberts1, Graham J. Kemp2, Margot A. Gosney3, Michael Lye3 and Graham H. Whitehouse1

1 Magnetic Resonance and Image Analysis Research Centre, , 2 Department of Musculoskeletal Science and , 3 Department of Geriatric Medicine, University of Liverpool, Liverpool, UK

Ageing is associated with reduction of grey matter volume and it is reported that the frontal lobes are preferentially affected. We have applied quantitative magnetic resonance spectroscopy (MRS), incorporating measurement of brain tissue water content and metabolite T2 relaxation times, to determine absolute concentrations of the putative neuronal marker N-acetylaspartate (NAA), creatine (Cr) and choline (Cho) compounds in the frontal lobe of 50 male subjects aged between 20 and 70 years (10 per decade). The fractional brain water content (ßMR) did not change significantly as a function of age (r = 0.07, P = 0.65) and had a mean value of 81% (CV = 2%). The concentration (in millimoles per litre brain tissue) of NAA decreased significantly with age (r = –0.42, P = 0.003), with an overall decrease of 12% between the third and seventh decades. The concentrations of Cr and Cho did not change significantly with age. The interpretation of the age-dependent decrease in NAA concentration as reflecting either a reduction in neuronal volume, number or function is discussed.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 RadiologyHome page
K. G. King, L. Glodzik, S. Liu, J. S. Babb, M. J. de Leon, and O. Gonen
Anteroposterior Hippocampal Metabolic Heterogeneity: Three-dimensional Multivoxel Proton 1H MR Spectroscopic Imaging--Initial Findings
Radiology, August 11, 2008; (2008) 2491071500.
[Abstract] [Full Text]

Home page
 J Geriatr Psychiatry NeurolHome page
L. Minati, M. Grisoli, and M. G. Bruzzone
MR Spectroscopy, Functional MRI, and Diffusion-Tensor Imaging in the Aging Brain: A Conceptual Review
J Geriatr Psychiatry Neurol, March 1, 2007; 20(1): 3 - 21.
[Abstract] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
A. J. Ross, P. S. Sachdev, W. Wen, and H. Brodaty
Longitudinal changes during aging using proton magnetic resonance spectroscopy.
J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2006; 61(3): 291 - 298.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
R. A. Charlton, T. R. Barrick, D. J. McIntyre, Y. Shen, M. O'Sullivan, F. A. Howe, C. A. Clark, R. G. Morris, and H. S. Markus
White matter damage on diffusion tensor imaging correlates with age-related cognitive decline
Neurology, January 24, 2006; 66(2): 217 - 222.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Alchanatis, N. Deligiorgis, N. Zias, A. Amfilochiou, E. Gotsis, A. Karakatsani, and A. Papadimitriou
Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study
Eur. Respir. J., December 1, 2004; 24(6): 980 - 986.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
P. E. Sijens, T. d. Heijer, D. Origgi, S. E. Vermeer, M. M. B. Breteler, A. Hofman, and M. Oudkerk
Brain Changes with Aging: MR Spectroscopy at Supraventricular Plane Shows Differences between Women and Men
Radiology, March 1, 2003; 226(3): 889 - 896.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. J. Ferguson, A. M. J. MacLullich, I. Marshall, I. J. Deary, J. M. Starr, J. R. Seckl, and J. M. Wardlaw
Magnetic resonance spectroscopy and cognitive function in healthy elderly men
Brain, December 1, 2002; 125(12): 2743 - 2749.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.