Cerebral Cortex, Vol. 11, No. 5, 441-451,
May 2001
© 2001 Oxford University Press
Fast Spiking and Regular Spiking Neural Correlates of Fear Conditioning in the Medial Prefrontal Cortex of the Rat
Neuroscience Laboratory, Institute for Medical Sciences, Ajou University School of Medicine, Suwon 442-721, , 1 Department of Psychology, Korea University, Seoul 136–701 and , 2 Brain Disease Research Center, Ajou University School of Medicine, Suwon 442-721, Korea
In order to investigate whether and how medial prefrontal cortex (mPFC) of the rat is involved in processing of information related to fear conditioning, we recorded from single units in the prelimbic and infralimbic cortex of fear-conditioned rats in response to an explicit conditional stimulus (CS; an auditory tone) or contextual cues (conditioning box). The majority of units changed their activities significantly in response to the CS in a delay or trace conditioning paradigm. Both transient and tonic activity changes, including delay cell activity, were observed as in other behavioral tasks. When exposed to the context without CS delivery, most units changed their activities as well. These results show that both tone and contextual information are processed in the rat mPFC in expectation of the delivery of an aversive stimulus (electric foot shock). Interestingly, fast spiking cells (putative inhibitory interneurons) and regular spiking cells (putative projection neurons) showed different patterns of responses. Fast spiking cells tended to show transient responses and increased their firing rates following CS presentation, whereas a complementary pattern was observed in the regular spiking cells. Our results enhance our understanding of the neural mechanisms underlying prediction of an aversive stimulus in the mPFC.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Burgos-Robles, I. Vidal-Gonzalez, and G. J. Quirk Sustained Conditioned Responses in Prelimbic Prefrontal Neurons Are Correlated with Fear Expression and Extinction Failure J. Neurosci., July 1, 2009; 29(26): 8474 - 8482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Narayanan and M. Laubach Delay Activity in Rodent Frontal Cortex During a Simple Reaction Time Task J Neurophysiol, June 1, 2009; 101(6): 2859 - 2871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Peters, P. W. Kalivas, and G. J. Quirk Extinction circuits for fear and addiction overlap in prefrontal cortex Learn. Mem., April 20, 2009; 16(5): 279 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Lodge, M. M. Behrens, and A. A. Grace A Loss of Parvalbumin-Containing Interneurons Is Associated with Diminished Oscillatory Activity in an Animal Model of Schizophrenia J. Neurosci., February 25, 2009; 29(8): 2344 - 2354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sui, J. Wang, and B.-M. Li Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex Learn. Mem., October 2, 2008; 15(10): 762 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. B. McGinty and A. A. Grace Selective Activation of Medial Prefrontal-to-Accumbens Projection Neurons by Amygdala Stimulation and Pavlovian Conditioned Stimuli Cereb Cortex, August 1, 2008; 18(8): 1961 - 1972. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Paz, E. P. Bauer, and D. Pare Theta synchronizes the activity of medial prefrontal neurons during learning Learn. Mem., July 8, 2008; 15(7): 524 - 531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. B. Kim, N. Huh, H. Lee, E. H. Baeg, D. Lee, and M. W. Jung Encoding of Action History in the Rat Ventral Striatum J Neurophysiol, December 1, 2007; 98(6): 3548 - 3556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Paz, E. P. Bauer, and D. Pare Learning-Related Facilitation of Rhinal Interactions by Medial Prefrontal Inputs J. Neurosci., June 13, 2007; 27(24): 6542 - 6551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Corcoran and G. J. Quirk Activity in Prelimbic Cortex Is Necessary for the Expression of Learned, But Not Innate, Fears J. Neurosci., January 24, 2007; 27(4): 840 - 844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Baeg, Y. B. Kim, J. Kim, J.-W. Ghim, J. J. Kim, and M. W. Jung Learning-Induced Enduring Changes in Functional Connectivity among Prefrontal Cortical Neurons J. Neurosci., January 24, 2007; 27(4): 909 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Vidal-Gonzalez, B. Vidal-Gonzalez, S. L. Rauch, and G. J. Quirk Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear Learn. Mem., November 1, 2006; 13(6): 728 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Laviolette and A. A. Grace Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs. J. Neurosci., June 14, 2006; 26(24): 6458 - 6468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Laviolette, W. J. Lipski, and A. A. Grace A Subpopulation of Neurons in the Medial Prefrontal Cortex Encodes Emotional Learning with Burst and Frequency Codes through a Dopamine D4 Receptor-Dependent Basolateral Amygdala Input J. Neurosci., June 29, 2005; 25(26): 6066 - 6075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Jackson, H. Homayoun, and B. Moghaddam NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex PNAS, June 1, 2004; 101(22): 8467 - 8472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Pezze, T. Bast, and J. Feldon Significance of Dopamine Transmission in the Rat Medial Prefrontal Cortex for Conditioned Fear Cereb Cortex, April 1, 2003; 13(4): 371 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. V. Williams, S. G. Rao, and P. S. Goldman-Rakic The Physiological Role of 5-HT2A Receptors in Working Memory J. Neurosci., April 1, 2002; 22(7): 2843 - 2854. [Abstract] [Full Text] [PDF]
|
|