Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (58)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hirayasu, Y.
Right arrow Articles by McCarley, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hirayasu, Y.
Right arrow Articles by McCarley, R. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol. 11, No. 4, 374-381, April 2001
© 2001 Oxford University Press

Prefrontal Gray Matter Volume Reduction in First Episode Schizophrenia

Yoshio Hirayasu1,2, Shin Tanaka1, Martha E. Shenton1,3, Dean F. Salisbury1,3, Massimo A. DeSantis3, James J. Levitt1, Cindy Wible1, Deborah Yurgelun-Todd4, Ron Kikinis5, Ferenc A. Jolesz5 and Robert W. McCarley1,3

1 Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Brockton VA Medical Center and Harvard Medical School, Brockton,MA, , 3 Cognitive Neuroscience Laboratory, McLean Hospital, Belmont, MA, , 4 Brain Imaging Center, McLean Hospital, Belmont, MA and , 5 Surgical Planning Laboratory, MRI Division, Brigham and Women's Hospital, Department of Radiology, Harvard Medical School, Boston, MA, USA

Functional measures have consistently shown prefrontal abnormalities in schizophrenia. However, structural magnetic resonance imaging (MRI) findings of prefrontal volume reduction have been less consistent. In this study, we evaluated prefrontal gray matter volume in first episode (first hospitalized) patients diagnosed with schizophrenia, compared with first episode patients diagnosed with affective psychosis and normal comparison subjects, to determine the presence in and specificity of prefrontal abnormalities to schizophrenia. Prefrontal gray and white matter volumes were measured from first episode patients with schizophrenia (n = 17), and from genderand parental socio-economic status-matched subjects with affective (mainly manic) psychosis (n = 17) and normal comparison subjects (n = 17), age-matched within a narrow age range (18–29 years). Total (left and right) prefrontal gray matter volume was significantly reduced in first episode schizophrenia compared with first episode affective psychosis and comparison subjects. Follow-up analyses indicated significant left prefrontal gray matter volume reduction and trend level reduction on the right. Schizophrenia patients showed 9.2% reduction on the left and 7.7% reduction on the right compared with comparison subjects. White matter volumes did not differ among groups. These data suggest that prefrontal cortical gray matter volume reduction is selectively present at first hospitalization in schizophrenia but not affective psychosis.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Schizophr BullHome page
S. Reig, C. Moreno, D. Moreno, M. Burdalo, J. Janssen, M. Parellada, A. Zabala, M. Desco, and C. Arango
Progression of Brain Volume Changes in Adolescent-Onset Psychosis
Schizophr Bull, January 24, 2008; (2008) sbm160v1.
[Abstract] [Full Text] [PDF]

Home page
 J Am Acad Psychiatry LawHome page
D. Bourget, P. Gagne, and M.-E. Labelle
Parricide: A Comparative Study of Matricide Versus Patricide
J Am Acad Psychiatry Law, September 1, 2007; 35(3): 306 - 312.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
A. M. Achim, M.-C. Bertrand, H. Sutton, A. Montoya, Y. Czechowska, A. K. Malla, R. Joober, J. C. Pruessner, and M. Lepage
Selective Abnormal Modulation of Hippocampal Activity During Memory Formation in First-Episode Psychosis
Arch Gen Psychiatry, September 1, 2007; 64(9): 999 - 1014.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
T. J. Whitford, S. M. Grieve, T. F.D. Farrow, L. Gomes, J. Brennan, A. W.F. Harris, E. Gordon, and L. M. Williams
Volumetric White Matter Abnormalities in First-Episode Schizophrenia: A Longitudinal, Tensor-Based Morphometry Study
Am J Psychiatry, July 1, 2007; 164(7): 1082 - 1089.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
R. E. Gur, M. S. Keshavan, and S. M. Lawrie
Deconstructing Psychosis With Human Brain Imaging
Schizophr Bull, July 1, 2007; 33(4): 921 - 931.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
M.-S. Koo, C. C. Dickey, H.-J. Park, M. Kubicki, N. Y. Ji, S. Bouix, K. M. Pohl, J. J. Levitt, M. Nakamura, M. E. Shenton, et al.
Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder.
Arch Gen Psychiatry, October 1, 2006; 63(10): 1090 - 1100.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
K. Dean, P. Fearon, K. Morgan, G. Hutchinson, K. Orr, X. Chitnis, J. Suckling, R. Mallet, J. Leff, P. B. Jones, et al.
Grey matter correlates of minor physical anomalies in the AeSOP first-episode psychosis study
The British Journal of Psychiatry, September 1, 2006; 189(3): 221 - 228.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
R. G. STEEN, C. MULL, R. MCCLURE, R. M. HAMER, and J. A. LIEBERMAN
Brain volume in first-episode schizophrenia: Systematic review and meta-analysis of magnetic resonance imaging studies
The British Journal of Psychiatry, June 1, 2006; 188(6): 510 - 518.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
C. Pantelis, M. Yucel, S. J Wood, D. Velakoulis, D. Sun, G. Berger, G. W Stuart, A. Yung, L. Phillips, and P. D McGorry
Structural Brain Imaging Evidence for Multiple Pathological Processes at Different Stages of Brain Development in Schizophrenia
Schizophr Bull, July 1, 2005; 31(3): 672 - 696.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
C. McDonald, E. Bullmore, P. Sham, X. Chitnis, J. Suckling, J. MacCabe, M. Walshe, and R. M. Murray
Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: Computational morphometry study
The British Journal of Psychiatry, May 1, 2005; 186(5): 369 - 377.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
R. A. Morey, S. Inan, T. V. Mitchell, D. O. Perkins, J. A. Lieberman, and A. Belger
Imaging Frontostriatal Function in Ultra-High-Risk, Early, and Chronic Schizophrenia During Executive Processing
Arch Gen Psychiatry, March 1, 2005; 62(3): 254 - 262.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
L. C. Wiegand, S. K. Warfield, J. J. Levitt, Y. Hirayasu, D. F. Salisbury, S. Heckers, S. Bouix, D. Schwartz, M. Spencer, C. C. Dickey, et al.
An In Vivo MRI Study of Prefrontal Cortical Complexity in First-Episode Psychosis
Am J Psychiatry, January 1, 2005; 162(1): 65 - 70.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
D. R Hemsley
The Schizophrenic Experience: Taken Out of Context?
Schizophr Bull, January 1, 2005; 31(1): 43 - 53.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
A. C. James, S. James, D. M. Smith, and A. Javaloyes
Cerebellar, Prefrontal Cortex, and Thalamic Volumes Over Two Time Points in Adolescent-Onset Schizophrenia
Am J Psychiatry, June 1, 2004; 161(6): 1023 - 1029.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
C. Gaser, I. Nenadic, H.-P. Volz, C. Buchel, and H. Sauer
Neuroanatomy of 'Hearing Voices': A Frontotemporal Brain Structural Abnormality Associated with Auditory Hallucinations in Schizophrenia
Cereb Cortex, January 1, 2004; 14(1): 91 - 96.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
S. A. Mitelman, L. Shihabuddin, A. M. Brickman, E. A. Hazlett, and M. S. Buchsbaum
MRI Assessment of Gray and White Matter Distribution in Brodmann's Areas of the Cortex in Patients With Schizophrenia With Good and Poor Outcomes
Am J Psychiatry, December 1, 2003; 160(12): 2154 - 2168.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
K. Kasai, M. E. Shenton, D. F. Salisbury, T. Onitsuka, S. K. Toner, D. Yurgelun-Todd, R. Kikinis, F. A. Jolesz, and R. W. McCarley
Differences and Similarities in Insular and Temporal Pole MRI Gray Matter Volume Abnormalities in First-Episode Schizophrenia and Affective Psychosis
Arch Gen Psychiatry, November 1, 2003; 60(11): 1069 - 1077.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
K. Kasai, M. E. Shenton, D. F. Salisbury, Y. Hirayasu, T. Onitsuka, M. H. Spencer, D. A. Yurgelun-Todd, R. Kikinis, F. A. Jolesz, and R. W. McCarley
Progressive Decrease of Left Heschl Gyrus and Planum Temporale Gray Matter Volume in First-Episode Schizophrenia: A Longitudinal Magnetic Resonance Imaging Study
Arch Gen Psychiatry, August 1, 2003; 60(8): 766 - 775.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
S. Miyamoto, A. S. LaMantia, G. E. Duncan, P. Sullivan, J. H. Gilmore, and J. A. Lieberman
Recent Advances in the Neurobiology of Schizophrenia
Mol. Interv., February 1, 2003; 3(1): 27 - 39.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
L. D. Selemon, J. Mrzljak, J. E. Kleinman, M. M. Herman, and P. S. Goldman-Rakic
Regional Specificity in the Neuropathologic Substrates of Schizophrenia: A Morphometric Analysis of Broca's Area 44 and Area 9
Arch Gen Psychiatry, January 1, 2003; 60(1): 69 - 77.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. PsychiatryHome page
L. D. Selemon, J. E. Kleinman, M. M. Herman, and P. S. Goldman-Rakic
Smaller Frontal Gray Matter Volume in Postmortem Schizophrenic Brains
Am J Psychiatry, December 1, 2002; 159(12): 1983 - 1991.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.