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Cerebral Cortex, Vol. 10, No. 7, 714-726, July 2000
© 2000 Oxford University Press

Congenital Auditory Deprivation Reduces Synaptic Activity within the Auditory Cortex in a Layer-specific Manner

A. Kral1,2, R. Hartmann1, J. Tillein1, S. Heid1 and R. Klinke1

1 Physiologisches Institut III, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany and , 2 Institute of Pathological Physiology, Sasinkova 4, SK-811 08 Bratislava, Slovak Republic

The present study investigates the functional deficits of naive auditory cortices in adult congenitally deaf cats. For this purpose, their auditory system was stimulated electrically using cochlear implants. Synaptic currents in cortical layers were revealed using current source density analyses. They were compared with synaptic currents found in electrically stimulated hearing cats. The naive auditory cortex showed significant deficits in synaptic activity in infragranular cortical layers. Furthermore, there was also a deficit of synaptic activities at longer latencies (>30 ms). The ‘cortical column’ was not activated in the well-defined sequence found in normal hearing cats. These results demonstrate functional deficits as a consequence of congenital auditory deprivation. Similar deficits are likely in congenitally deaf children.


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