Cerebral Cortex, Vol. 10, No. 3, 326-333,
March 2000
© 2000 Oxford University Press
Orbital and Medial Prefrontal Cortex and Psychostimulant Abuse: Studies in Animal Models
Center for the Neurobiological Investigation of Abused Drugs, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
One approach to pursuing questions about the neural substrates that support substance abuse-related behaviors involves the use of animal models. Carefully controlled animal experiments can be conducted without the confounds commonly found in studies of human addicts, such as polydrug abuse, variable drug history and premorbid psychiatric conditions. The present paper considers the orbitofrontal and related limbic prefrontal cortex in the context of such models of substance abuse. First, the importance of recognizing the heterogeneous structural and functional nature of orbitofrontal cortex in both rodents and primates is addressed, and the results of studies involving the prefrontal cortex in substance abuse-related behaviors are considered in light of this diversity. Second, data from metabolic mapping studies are described that indicate that the pattern of functional activity within medial and orbitofrontal cortex shifts as the duration of exposure to drugs such as cocaine is extended. These functional differences, in turn, may reflect progressive phases of the addictive process. In order to understand the neurobiological consequences of long-term drug use, it will be important to establish the differing roles played by distinct anatomical territories within orbital and medial prefrontal cortex during the course of chronic substance abuse.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Peters, P. W. Kalivas, and G. J. Quirk Extinction circuits for fear and addiction overlap in prefrontal cortex Learn. Mem., April 20, 2009; 16(5): 279 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J.R Beveridge, K. E Gill, C. A Hanlon, and L. J Porrino Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys Phil Trans R Soc B, October 12, 2008; 363(1507): 3257 - 3266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Liu, R. P. Heitz, A. R. Sampson, W. Zhang, and C. W. Bradberry Evidence of Temporal Cortical Dysfunction in Rhesus Monkeys following Chronic Cocaine Self-Administration Cereb Cortex, September 1, 2008; 18(9): 2109 - 2116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Homayoun and B. Moghaddam Progression of Cellular Adaptations in Medial Prefrontal and Orbitofrontal Cortex in Response to Repeated Amphetamine J. Neurosci., August 2, 2006; 26(31): 8025 - 8039. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Hurliman, J. C. Nagode, and J. V. Pardo Double Dissociation of Exteroceptive and Interoceptive Feedback Systems in the Orbital and Ventromedial Prefrontal Cortex of Humans J. Neurosci., May 4, 2005; 25(18): 4641 - 4648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Sawamura, T. Sawamura-Yamamoto, Y. Ozeki, C. A. Ross, and A. Sawa A form of DISC1 enriched in nucleus: Altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse PNAS, January 25, 2005; 102(4): 1187 - 1192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Porrino, D. Lyons, H. R. Smith, J. B. Daunais, and M. A. Nader Cocaine Self-Administration Produces a Progressive Involvement of Limbic, Association, and Sensorimotor Striatal Domains J. Neurosci., April 7, 2004; 24(14): 3554 - 3562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pears, J. A. Parkinson, L. Hopewell, B. J. Everitt, and A. C. Roberts Lesions of the Orbitofrontal but not Medial Prefrontal Cortex Disrupt Conditioned Reinforcement in Primates J. Neurosci., December 3, 2003; 23(35): 11189 - 11201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Killcross and E. Coutureau Coordination of Actions and Habits in the Medial Prefrontal Cortex of Rats Cereb Cortex, April 1, 2003; 13(4): 400 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Porrino, D. Lyons, M. D. Miller, H. R. Smith, D. P. Friedman, J. B. Daunais, and M. A. Nader Metabolic Mapping of the Effects of Cocaine during the Initial Phases of Self-Administration in the Nonhuman Primate J. Neurosci., September 1, 2002; 22(17): 7687 - 7694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Adinoff, M. D. Devous Sr., S. M. Best, M. S. George, D. Alexander, and K. Payne Limbic Responsiveness to Procaine in Cocaine-Addicted Subjects Am J Psychiatry, March 1, 2001; 158(3): 390 - 398. [Abstract] [Full Text]
|
|
|
|
|
|
N. D. Volkow and J. S. Fowler Addiction, a Disease of Compulsion and Drive: Involvement of the Orbitofrontal Cortex Cereb Cortex, March 1, 2000; 10(3): 318 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Kruzich and R. E. See Differential Contributions of the Basolateral and Central Amygdala in the Acquisition and Expression of Conditioned Relapse to Cocaine-Seeking Behavior J. Neurosci., July 15, 2001; 21(14): RC155 - RC155. [Abstract] [Full Text] [PDF]
|
|