Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (26)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Van Hoesen, G. W.
Right arrow Articles by Chu, C.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Van Hoesen, G. W.
Right arrow Articles by Chu, C.-C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Cerebral Cortex, Vol. 10, No. 3, 243-251, March 2000
© 2000 Oxford University Press

Orbitofrontal Cortex Pathology in Alzheimer's Disease

Gary W. Van Hoesen1,2, Josef Parvizi2 and Ching-Chiang Chu2

1 Department of Anatomy and Cell Biology, University of Iowa and , 2 Division of Cognitive Neuroscience, Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA

The orbitofrontal cortex has been examined in Alzheimer's disease (AD) from the viewpoint of neurofibrillary tangle (NFT) pathology, its laminar distribution and topography. NFT pathology in the orbitofrontal cortex is extensive in AD. In cases with extensive cortical pathology, NFTs extend from the pole of the frontal lobe to the orbitoinsular junction. In lesser affected cases, the anterior granular part of the orbital cortex is less invested by NFTs. Layers III and V contain the greatest density of NFTs and these are most dense in the dysgranular areas, posterior to the transverse orbital sulcus. Posterior and medial orbitofrontal areas, forming area 13 and the posterior tip of the paraolfactory gyrus, are the most severely damaged, as are the smaller agranular fields that surround the olfactory tract and cortex. The widespread orbitofrontal damage in AD affecting projection neurons suggests that this pathology may contribute heavily to the many non-memory-related behavior changes observed in this disorder.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Cereb CortexHome page
J. P. Lerch, J. C. Pruessner, A. Zijdenbos, H. Hampel, S. J. Teipel, and A. C. Evans
Focal Decline of Cortical Thickness in Alzheimer's Disease Identified by Computational Neuroanatomy
Cereb Cortex, July 1, 2005; 15(7): 995 - 1001.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
S. J. Choi, K. O. Lim, I. Monteiro, and B. Reisberg
Diffusion Tensor Imaging of Frontal White Matter Microstructure in Early Alzheimer's Disease: A Preliminary Study
J Geriatr Psychiatry Neurol, March 1, 2005; 18(1): 12 - 19.
[Abstract] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
C Brenneis, K Seppi, M Schocke, T Benke, G K Wenning, and W Poewe
Voxel based morphometry reveals a distinct pattern of frontal atrophy in progressive supranuclear palsy
J. Neurol. Neurosurg. Psychiatry, February 1, 2004; 75(2): 246 - 249.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
H. Matsuda, N. Kitayama, T. Ohnishi, T. Asada, S. Nakano, S. Sakamoto, E. Imabayashi, and A. Katoh
Longitudinal Evaluation of Both Morphologic and Functional Changes in the Same Individuals with Alzheimer's Disease
J. Nucl. Med., March 1, 2002; 43(3): 304 - 311.
[Abstract] [Full Text] [PDF]

Home page
 AM J ALZHEIMERS DIS OTHER DEMENHome page
L. E. Nee and C. F. Lippa
Inherited Alzheimer's disease PS-1 olfactory function: A 10-year follow-up study
American Journal of Alzheimer's Disease and Other Dementias, March 1, 2001; 16(2): 83 - 84.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.