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Cerebral Cortex, Vol. 10, No. 12, 1200-1210, December 2000
© 2000 Oxford University Press

Regional Size Reduction in the Human Corpus Callosum Following Pre- and Perinatal Brain Injury

Pamela Moses1, Eric Courchesne2,3, Joan Stiles1, Doris Trauner3, Brian Egaas2 and Erik Edwards2

1 Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92093, , 2 Laboratory for Research on the Neuroscience of Autism, Children's Hospital Research Center, San Diego, CA 92123 and , 3 Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA

This morphometric study examined two aspects of corpus callosum development: pediatric cortico-callosal topography and developmental neuroplasticity subsequent to perinatal brain injury. In vivo magnetic resonance imaging was used to quantify the total midsagittal cross-sectional area and five anterioposterior subregions of the callosum in 10 children with focal lesions and 86 healthy volunteer control subjects. Nine of the ten children with early injury showed a reduction in the total area of the callosum relative to matched controls. The area of the total callosum cross-section was inversely proportional to the size of lesion. All patients displayed region-specific size reduction. This regional thinning bore a topographical relationship to the lesion sites. Reduction in anterior subregions 1, 2 and 3 was respectively associated with lesions in the anterior inferior frontal area, the middle and superior frontal region, and the precentral area. Attenuation of subregion 4 corresponded to anterior parietal lesions, and thinning of subregion 5 occurred with posterior parietal injury. This cortical-callosal pattern coincides with adult and nonhuman primate mappings. Callosal thinning despite the early onset of the lesions suggests limits to developmental neuroplasticity.


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