Cerebral Cortex 1991; 1:463-468
© Oxford University Press 1991
research-article |
Separate Progenitor Cells Give Rise to Pyramidal and Nonpyramidal Neurons in the Rat Telencephalon
1Department of Anatomy and Developmental Biology, University College London London WZ1E 6BT, 2Department of Anatomy and Cell Biology, and Pediatrics, Emory University School of Medicine Atlanta, Georgia 30322
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, U.K.
Neurons of the mammalian cerebral cortex are commonly subdivided into two broad classes: pyramidal and nonpyramidal. The former are projection neurons, while the latter are interneurons. To determine whether the two neuronal classes in the cerebral cortex are derived from the same or separate progenitor cells, we used a recombinant retrovirus containing the reporter gene E-coli ß-galactosidase as a lineage marker. Clonally related neurons expressing the inherited ß-galactosidase gene were detected histochemically, at both light and electron microscopic levels, and their phenotypes were identified using well-established ultrastructural criteria. The clones examined, with one exception, were composed of either all pyramidal or all nonpyramidal neurons. These findings suggest that pyramidal and nonpyramidal neurons in the cerebral cortex have separate lineages and are derived from different progenitor cells in the ventricular zone. This lends weight to the notion that cells in the ventricular zone comprise a heteroge neous population, and that lineage contributes substantially to the phenotype of a neuron.
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