Cerebral Cortex 1991; 1:380-389
© Oxford University Press 1991
research-article |
A Comparison of Pattern Formation by Thalamocortical and Serotonergic Afferents in the Rat Barrel Field Cortex
1The Kennedy Research Institute and the Department of Neurology, The Johns Hopkins University School of Medicine Baltimore, Maryland 21205, 2Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology Cambridge, Massachusetts 02139
Neuroscience Laboratory, The Kennedy Research Institute, 707 North Broadway, Baltimore, MD 21205.
E25-634, MIT, Cambridge, MA 02139.
In the present study we compare the formation of vibrissa-related patterns by thalamocortical afferents from the ventrobasal (VB) nucleus to that by raphe-cortical, serotonergic afferents from the raphe nuclei. In opposite hemispheres of the same brain, 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (Dil) labeling of VB afterents and serotonin (5-HT) immunohistochemistry reveal that the pattern of vibrissa-specific patches is first exhibited by thalamocortical axons in barrel field cortex. Shortly thereafter, 5-HT axons form patches in the same locations as the dense concentrations of VB afferents.
To assess a possible role of 5-HT afterents in the specification of barrel field cortex, neonatal rat pups were administered p-chloroamphetamine (PCA), a selective 5-HT neurotoxin. The formation of vibrissa-related patterns by thalamocortical and serotonergic afferents was compared in normal and PCA-treatod rat pups at various developmental stages. PCA treatment led to a significant decrease in the number of serotonergic axons in barrel field cortex. Despite this decrease, VB afferents segregated in patches over individual barrels. However, a delay in the emergence of the thalamocortical pattern was noted in toxin-treated animals. We conclude that PCA treatment does not prevent formation of a vibrissa-specific pattern by thalamocortical aft erents, and discuss the possibility that the 5-HT axons may play atrophic role in the maturation of VB afferents.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Esaki, M. Cook, K. Shimoji, D. L. Murphy, L. Sokoloff, and A. Holmes Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice PNAS, April 12, 2005; 102(15): 5582 - 5587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. L. Donovan, L. A. Mamounas, A. M. Andrews, M. E. Blue, and J. S. McCasland GAP-43 Is Critical for Normal Development of the Serotonergic Innervation in Forebrain J. Neurosci., May 1, 2002; 22(9): 3543 - 3552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Persico, E. Mengual, R. Moessner, S. F. Hall, R. S. Revay, I. Sora, J. Arellano, J. DeFelipe, J. M. Gimenez-Amaya, M. Conciatori, et al. Barrel Pattern Formation Requires Serotonin Uptake by Thalamocortical Afferents, and Not Vesicular Monoamine Release J. Neurosci., September 1, 2001; 21(17): 6862 - 6873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Salichon, P. Gaspar, A. L. Upton, S. Picaud, N. Hanoun, M. Hamon, E. De Maeyer, D. L. Murphy, R. Mossner, K. P. Lesch, et al. Excessive Activation of Serotonin (5-HT) 1B Receptors Disrupts the Formation of Sensory Maps in Monoamine Oxidase A and 5-HT Transporter Knock-Out Mice J. Neurosci., February 1, 2001; 21(3): 884 - 896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Wilson, M. V. Johnston, G. W. Goldstein, and M. E. Blue Neonatal lead exposure impairs development of rodent barrel field cortex PNAS, May 9, 2000; 97(10): 5540 - 5545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.M. Persico, C. Altamura, E. Calia, S. Puglisi-Allegra, R. Ventura, F. Lucchese, and F. Keller Serotonin Depletion and Barrel Cortex Development: Impact of Growth Impairment vs. Serotonin Effects on Thalamocortical Endings Cereb Cortex, February 1, 2000; 10(2): 181 - 191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Upton, N. Salichon, C. Lebrand, A. Ravary, R. Blakely, I. Seif, and P. Gaspar Excess of Serotonin (5-HT) Alters the Segregation of Ispilateral and Contralateral Retinal Projections in Monoamine Oxidase A Knock-Out Mice: Possible Role of 5-HT Uptake in Retinal Ganglion Cells During Development J. Neurosci., August 15, 1999; 19(16): 7007 - 7024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-Y. Wu, G. E. Schneider, J. Silver, M. Poston, and S. Jhaveri A Role for Tectal Midline Glia in the Unilateral Containment of Retinocollicular Axons J. Neurosci., October 15, 1998; 18(20): 8344 - 8355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Brock, M. E. Blue, C. J. Lowenstein, F. A. Northington, M. S. Lange, M. V. Johnston, and W. A. Baumgartner Induction of Neuronal Nitric Oxide After Hypothermic Circulatory Arrest Ann. Thorac. Surg., November 1, 1996; 62(5): 1313 - 1320. [Abstract] [Full Text]
|
|
|
|
|
|
T. L. Whitworth, L. C. Herndon, and M. W. Quick Psychostimulants Differentially Regulate Serotonin Transporter Expression in Thalamocortical Neurons J. Neurosci., January 1, 2002; 22(1): RC192 - RC192. [Abstract] [Full Text] [PDF]
|
|