Cerebral Cortex 1991; 1:221-229
© Oxford University Press 1991
research-article |
The Alignment of Migrating Neural Cells in Relation to the Murine Neopallial Radial Glial Fiber System
1Department of Neurology, Developmental Neurobiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02 114, 2Laboratory of Physiology and Developmental Neurobiology, University of Liege School of Medicine B-4000 Liege, Belgium, 3Department of Genetics, Harvard Medical School Boston, Massachusetts 02115
Correspondence should be addressed to Takao Takahashi, Department of Neurology, Developmental Neurobiology, Massachusetts General Hospital, Boston, MA02114.
The direction of neural cell migration in relation to the pattern of alignment of adjacent radial glial fibers has been studied in the developing neopallium of emhryonic days 16-18 mouse embryos. The radial glial fibers were stained with RC2, a monoclonal antibody selective for cells of astroglial lineage in the developing murine brain. Migrating neural cells were stained histochemically with 5-bromo-4-chloro-3-indolyl-ß-D-galactopyranoside (X-gal) following retroviral transduction of the gene encoding ß-galactosidase into proliferating progenitors on E13. The leading processes and, generally, the somata of migrating neurons were found to he aligned in parallel with the radial glial fibers, despite substantial variations in the patterns of alignment of the fiber fascicles. The set of observations is consistent with the hypothesis that neural cell migration is supported by radial glial fibers.
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